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BI-9321 trihydrochloride
CAS No. 2387510-87-2
BI-9321 trihydrochloride( —— )
Catalog No. M32809 CAS No. 2387510-87-2
BI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 68 | Get Quote |
|
| 5MG | 101 | Get Quote |
|
| 10MG | 180 | Get Quote |
|
| 25MG | 342 | Get Quote |
|
| 50MG | 579 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameBI-9321 trihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionBI-9321 trihydrochloride (BI9321 trihydrochloride) is a selective and potent NSD3-PWWP1 antagonist that downregulates Myc messenger RNA expression and reduces proliferation in MOLM-13 cells.
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DescriptionBI-9321 trihydrochloride is a potent, selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist with a Kd value of 166 nM. BI-9321 trihydrochloride is inactive against NSD2-PWWP1 and NSD3-PWWP2. BI-9321 trihydrochloride specifically disrupts histone interactions of theNSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells.
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorHistone Methyltransferase
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Research Area——
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Indication——
Chemical Information
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CAS Number2387510-87-2
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Formula Weight469.81
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Molecular FormulaC22H24Cl3FN4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 250 mg/mL (532.13 mM; Ultrasonic ) H2O : 25 mg/mL (53.21 mM; Ultrasonic)
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SMILESCl.Cl.Cl.Cc1cc(CN)cc(C)c1-c1ncn(C)c1-c1ccnc2cc(F)ccc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. B?ttcher J, et al. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3. Nat Chem Biol. 2019 Aug;15(8):822-829.?
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